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Research

Selected Published Research on Health and Muscadine Grapes

  • Paller CJ, Rudek, MA, Zhou XC, Wagner WD, Hudson TS, Anders N, Hammers HJ, Dowling D, King S, Antonarakis ES, Drake CG, Eisenberger MA, Denmeade SR, Rosner GL, Carducci MA. A phase I study of muscadine grape skin extract in men with biochemically recurrent prostate cancer: safety, tolerability, and dose determination. Prostate. 2015:75(14);1518-1520. DOI: 10.1158/1078-0432.CCR-17-1100
  • Paller CJ, Zhou XXC, Heath E, Taplin ME, Mayer TM, Stein MN, Bubley GJ, Pili R, Hudson TS, Kakarla R,  Abbas M, Anders N, Dowling D, King S, Bruns AB, Wagner WD, Drake CG, Antonarakis ES, Eisenberger MA, Denmeade SR, Rudek MA, Rosner GL, Carducci MA. Muscadine Grape Skin Extract in Men with Biochemically Recurrent Prostate Cancer: A Randomized, Multicenter, Placebo-Controlled Clinical Trail.  Clinical Cancer Research. 2018:24(2); 306-315. DOI: 10.1158/1078-0432.CCR-17-1100
  • Ignacio DN, Mason KD, Hackett-Morton EC, Albanese C, Ringer L, Wagner WD, Wang PC, Carducci MA, Kachhap SK, Paller CJ, Mendonca J, Li-Ying Chan L, Lin B, Hartle DK, Green JE, Brown CA, Hudson TS. Muscadine grape skin extract inhibits prostate cancer cells by inducing cell-cycle arrest, and decreasing migration through heat shock protein 40. Heliyon. 2019 Jan 16;5(1):e01128. DOI: 10.1016/j.heliyon.2019.e01128
  • Carsten RE, Bachand SM, Bailey SM, Le, PN, Robert N, Ullrich, RL  Resveratrol and muscadine grape extract reduce radiation-induced bone marrow PU.1 gene loss and chromosome aberration frequency Cancer research annual meeting abstract 2009.
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